Research Critique Part 2 Essay Example | Topics and Well Written Essays - 750 words

Research Critique Part 2 - Essay Example The study is from the journal of the American College of Obstetricians and Gynecologists published in 2006. While HPV-16 vaccine has been shown to significantly prevent persistent HPV infections, the ultimate objective of the study is to validate whether the vaccine is also effective to prevent cervical intraepithelial neoplasia (CIN) 2-3. In this study, risks and benefits especially on the use of placebo were identified and presented to participants. Voluntary participation was noted and participants were tested on HPV-16 infection before the onset of the study. Institutional approval was also obtained for a period of up to 48 months. Furthermore, informed consent was secured from the participating women and was readily available for revocation once the participant opts to withdraw from the study. In fact, 94 women were actually dropped from the list of participants due to consent withdrawal. Thus, although the study aimed at producing an acceptable evidence to promote the utilization of HPV-16 vaccine, human rights were still taken as of primary importance and the rights of the participants to withdraw from the study was exercised. The variables are explicitly stated in the research title and resemble the exposure variable and outcome variable. The independent variable includes the type of treatment applied, either the vaccine or the placebo depending on what the participant actually received. The incidence of cervical intraepithelial neoplasia (CIN) 2-3 was compared among the two treatment groups and therefore served as the dependent variable of the study. The data collection method was scheduled on day 1, month 7, and then 6-monthly thereafter until the 48th month. Genital samples for HPV-16 DNA, Pap tests, and antibody titers were collected during each collection time. This method was specifically formulated because CIN 2-3 may need a certain period